How to Layer Active Ingredients Without Irritating Skin

Introduction

Combining multiple actives can amplify skincare results but also increases irritation risk if mismanaged. Proper layering and timing are key. This guide details the order, pairing rules, and timing strategy to enjoy potent performance with minimal sensitivity.

Understanding pH and Compatibility

  • AHA/BHA (pH ~3–4) vs. Vitamin C (pH ~2.5–3.5) vs. Retinol (neutral pH)
  • Wait times and buffering
  • pH in skincare study (https://www.ncbi.nlm.nih.gov)

Morning Routine Order

  1. Cleanser
  2. Vitamin C serum (ISDIN Flavo-C)
  3. Hydrator (Hyalceutic)
  4. Sunscreen (Coola SPF)
  5. Vitamin C Serums

Evening Routine Order

  1. Cleanser
  2. AHA/BHA exfoliant (Dermaceutic Phyto-AH)
  3. Wait 20 minutes
  4. Retinol (Dermaceutic Active Retinol)
  5. Moisturizer
  6. Retinol Collection

Troubleshooting Sensitivity

  • Introduce one active at a time
  • Use hydrating masks to soothe
  • Adjust frequency based on skin response
  • Clean/Natural Collection

Conclusion & CTA

With the right layering strategy, you can safely combine potent actives for transformative results. Discover our active ingredient collections at The Dermatology Store.